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CALCINEURIN A
Descriptors Found:
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DeCS
Descriptor
English
:
Calcineurin
Descriptor
Spanish
:
Calcineurina
Descriptor
Portuguese
:
Calcineurina
Synonyms
English
:
Protein Phosphatase 3
Protein Phosphatase 3 Catalytic Subunit
Protein Phosphatase 3 Regulatory Subunit
Phosphatase 3, Protein
Protein Phosphatase 2B
Calcineurin A
Calcineurin B
Protein Phosphatase-2B
Tree Number:
D08.811.277.352.650.625.150
D12.644.360.087
D12.776.476.087
Definition
English
:
A
CALCIUM
and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the
calcineurin
A catalytic subunit and the
calcineurin
B regulatory subunit.
Calcineurin
has been shown to dephosphorylate a number of
phosphoproteins
including
HISTONES
; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT
PROTEIN KINASES
. It is involved in the regulation of
signal transduction
and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Entry Combination - descr/qualif
English
:
Calcineurin
/
antagonists & inhibitors
use
Calcineurin Inhibitors
History Note
English
:
98; see CALCINEURIN (NM) 1987-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33429
Unique Identifier:
D019703
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS